HONEY, PART 2 - Honey And Herpes, Worth A Look
G. Douglas Andersen, DC, DACBSP, CCN
Volume 23, Number 7, 3/26/05, page 32
It is estimated that one third of the world's population has been affected by the herpes simplex
virus.1 Honey has a long history in folk medicine as being a cure for many conditions,
especially those involving the skin. As a topical agent, honey has accelerated wound healing and reduced
scar formation following surgery.2 Dandruff and seborrheic dermatitis have also been
successfully treated by the same author.3 Combined with olive oil and beeswax, the author
states that it has worked very successfully in such chronic skin conditions as eczema, psoriasis, and
Sixteen volunteers (8 women and 8 men) with a history of labial and genital herpes outbreaks volunteered for
this study.5 The men averaged 6 outbreaks of genital herpes per year and the women averaged 5
outbreaks of labial herpes yearly. The length of resolution without intervention ranged from 7 to 12 days in
this small sample. Population averages state that the time to healing without treatment is 10 days. Half of
the 16 volunteers were asked to use honey on their next outbreak, the other half used 5% acyclovir cream. They
then employed the opposite intervention on their following outbreaks. Therapy was applied as
follows: Acyclovir cream was rubbed on the lesions 6 times per day. Gauze soaked in honey was placed on
the lesions 15 minutes 4 times a day. All subjects reported to the doctor within 24 hours of the onset of
their outbreak. They were monitored daily and their lesions were classified as macula, papule, vesicle,
pustule, ulcer, crust, and healed.
||Days of Attack
||Days of Pain
||Days to Resolution
Although this study is very impressive, it must be noted that it was not blinded. It also contained only
16 subjects and should be validated with a larger sample size. The researchers were not exactly sure why the
honey worked so well, but they had some theories, the first of which is that honey has been shown to reduce
two series prostaglandins6 which can negatively affect the immune system by inhibiting T cell
The other possible mechanism of action, either alone or in concert with what was described above, is honey’s
affect on nitric oxide. Honey contains nitric oxide metabolites.8 Honey can also elevate nitric
oxide in body fluids.9,10 Nitric oxide may retard or prevent replication of some viruses according
to the author.5
MAYBE THAT'S WHY THEY CALL IT HONEY...
Nitric oxide (NO) has been in the news lately. I remember learning years ago that the amino acid arginine
seemed to help the immune response during times of viral overload. Later, it was discovered arginine was a
precursor to endothelium derived relaxing factor (EDRF), a group of substances one of which was later
determined to be NO. If NO is indeed antiviral, this would not only explain why honey helped against Herpes,
but also explain why arginine has been used as a natural treatment for viruses.
A few years ago, when researchers were testing a drug for hypertension (sildenafil citrate), male subjects
noticed a rather profound side effect. If their minds wandered to thoughts of the opposite gender, a marked
increase in blood flow to a certain anatonical region was clearly noticed. It turns out this drug increases
NO, which resulted in relaxation of the corpus cavernosum. The trade name for this drug is Viagra. Could it
be that honey got its name for something other than taste?
1Whitley, J., Kimberlin, W., Roizman, B. Herpes Simplex Virus. Clin. Infect. Dis. 1998; 26: 541-555.
2Al-Waili, N.S., Saloom, K. Effects of Topical Honey on Postoperative Wound Infections Due to Gram Positive and Gram Negative Bacteria Following Cesarean Section and Hysterectomy. Eur. J. Med. Res. 1999; 4: 126-130.
3Al-Waili, N.S. Therapeutic and Prophylactic Effects of Crude Honey on Chronic Seborrheic Dermatitis. Eur. J. Med. Res. 2001; 7: 306-308.
4Al-Waili, N.S., Lootah, A., Shaheen, W. Mixture of Crude Honey and Olive Oil in Natural Wax to Treat Chronic Skin Disorders. Faseb J. 1999; 13A: 846.
5Al-Waili, N.S. Topical Honey Application Versus Acyclovir for the Treatment of Recurrent Herpes Simplex Lesions. Med. Sci. Monit. 2004; 10(8): 94-98.
6Al-Waili, N.S., Boni, N. Natural Honey Lowers Plasma Prostaglandin Concentration in Normal Individuals. J. Med. Food. 2003; 6: 129-135.
7Baker, D., Thomas, J. The Effect of Prostaglandin E2 on the Initial Immune Response to Herpes Simplex Virus Infections. Am. J. Obstet. Gynecol. 1985; 151: 586-590.
8Al-Waili, N.S. Identification of Nitric Oxide Metabolites in Various Honeys: Effects of Intravenous Honey on Plasma and Urinary Nitric Oxide Metabolite Concentrations. J. Med. Food. 2003; 6: 359-364.
9Al-Waili, N.S. Effects of Honey Ingestion of Nitric Oxide in Saliva. Faseb J. 2003; 17A: 767.
10Al-Waili, N.S., Boni, N. Effects of Honey on Blood and Urinary Nitric Oxide in Normal Individuals. Faseb J. 2003; 17A: 660.
E. Imperial Hwy.
Brea, CA. 92821
2004, G. Douglas Andersen, DC, DACBSP, CCN, 916 E. Imperial Hwy, Brea,
CA 92821, (714) 990-0824